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Watch this video to learn more about Dravet syndrome.
Dravet Syndrome Overview
Dravet syndrome is a rare, treatment-resistant developmental epileptic encephalopathy with onset in infancy and serious neurodevelopmental, motor, cognitive, and behavioral consequences that persist into adulthood.1,2
The number of infants born with Dravet syndrome in the United States3
Seizures associated with Dravet syndrome:1
Begin within the first year of life
Can be prolonged—sometimes lasting more than 5 minutes
Present in a developmentally normal infant
The impact of Dravet syndrome differs from patient to patient, with seizure frequency and severity, cognitive and behavioral skills, and response to treatment varying widely and evolving over time.1,2,4
For additional information about Dravet syndrome, please visit Dravet Syndrome Foundation (DSF) at DravetFoundation.org. The mission of Dravet Syndrome Foundation is to aggressively raise funds for Dravet syndrome and related epilepsies; to support and fund research; to increase awareness; and to provide support to affected individuals and families.
IMPORTANCE OF EARLY DIAGNOSIS
Early diagnosis (preferably within the first 2 years of life), aided by genetic testing, may lead to improved seizure control and cognitive and behavioral outcomes over the long term.4
The approximate percentage of children diagnosed with Dravet syndrome who carry SCN1A gene mutations4
Because children with Dravet syndrome may not show symptoms at birth, their condition often can go undiagnosed or misdiagnosed for months.
Misdiagnosis can lead to use of inappropriate treatment. Sodium channel blockers such as carbamazepine, oxcarbazepine, lamotrigine, and phenytoin can actually exacerbate seizures in Dravet syndrome.2,4
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- Dravet C. The core Dravet syndrome phenotype. Epilepsia. 2011;52(suppl 2):3-9. https://www.ncbi.nlm.nih.gov/pubmed/21463272
- Dravet C. Dravet syndrome history. Dev Med Child Neurol. 2011;53(suppl 2):1-6. https://www.ncbi.nlm.nih.gov/pubmed/21504424
- Wu YW, Sullivan J, McDaniel SS, et al. Incidence of Dravet syndrome in a US population. Pediatrics. 2015;136(5):e1310-e1315. https://www.ncbi.nlm.nih.gov/pubmed/26438699
- Wirrell EC, Laux L, Donner E, et al. Optimizing the diagnosis and management of Dravet syndrome: recommendations from a North American Consensus Panel. Pediatr Neurol. 2017;68:18-34.e3. https://www.ncbi.nlm.nih.gov/pubmed/28284397