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Impact of Seizures

More than 90% of children with Dravet syndrome are not able to achieve freedom from their persistent seizures.1

HIGH SEIZURE FREQUENCY

Many patients experience multiple seizures on a weekly or even daily basis.1-3

45% of patients with Dravet syndrome experience 4 or more monthly tonic-clonic seizures

of patients experience 4 or more tonic-clonic seizures per month4

32% of patients with Dravet syndrome experience 4 or more monthly myoclonic seizures

of patients experience 4 or more myoclonic seizures per month4

High seizure frequency has been associated with:1,5

Higher incidence of cognitive and behavioral impairment in patients with Dravet syndrome

Higher incidence of cognitive and behavioral impairment

More emergency admissions among patients with Dravet syndrome

More emergency admissions and ambulance calls

Lower health-related quality of life in patients with Dravet syndrome

Lower patient health-related quality of life

PREMATURE MORTALITY

Dravet syndrome carries a high risk of premature mortality* due to sudden unexpected death in epilepsy (SUDEP), fatal status epilepticus, and accidents.2,6-8 The main SUDEP risk factors, including high frequency of convulsions and antiepileptic drug polytherapy, relate to epilepsy severity.7,9

Overall risk of death is 6x higher in Dravet syndrome patients than in the general epilepsy patient population

The amount by which the overall risk of death is increased compared with the general population of patients with epilepsy8,10

More than 50% of Dravet syndrome deaths are due to SUDEP

The percentage of deaths due to SUDEP8

73% of SUDEP deaths in Dravet syndrome occur before the age of 11

The percentage of SUDEP deaths in Dravet syndrome that occur before the age of 11 years7

58% of deaths due to SUDEP were sleep related

of deaths due to SUDEP are sleep-related events. Most often, SUDEP occurs when the patient has a seizure while lying prone in bed during the night or early morning hours11

86% of deaths due to SUDEP occur unwitnessed. Nocturnal monitoring devices or someone else sleeping in the room may reduce risk

of deaths due to SUDEP occur unwitnessed, suggesting that nocturnal monitoring devices or having someone else sleep in the same room might decrease the risk11,12

*The mortality rate in Dravet syndrome was 15.84 per 1000 person-years (calculated over a total of 1073 person-years).8

There is an urgent need for continued research to help provide:

Continued research in Dravet syndrome can help deliver meaningful, consistent, and sustained seizure reduction

Meaningful, consistent, and sustained seizure reduction

Continued research in Dravet syndrome can help reduce cognitive decline and long-term disability

Improvements to reduce cognitive decline and long-term disability in patients

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Continued research in Dravet syndrome can help increase patient and caregiver freedom and quality of life

Increased patient and caregiver quality of life

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References